(R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate
(R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl ester
CAS: 138108-72-2
Molecular Formula: C10H19NO3
(R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate - Names and Identifiers
(R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H19NO3 |
| Molar Mass | 201.26 |
| Density | 1.089 |
| Boling Point | 289.5±13.0 °C(Predicted) |
| Flash Point | 128.9°C |
| Water Solubility | Slightly soluble in water |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000241mmHg at 25°C |
| Appearance | Oil |
| Color | Clear Colourless to Pale Yellow Thick |
| pKa | 14.93±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.483 |
(R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate - Introduction
(R)-1-Boc-3-hydroxymethylpyrrolidine is an organic compound having the formula C12H22N2O3.
This compound is a white solid with a high melting and boiling point. It is stable at normal temperature and soluble in organic solvents such as chloroform and dimethylformamide.
(R)-1-Boc-3-hydroxymethylpyrrolidine is commonly used as an intermediate in drug synthesis and can be used to synthesize other compounds or drugs. As the source of the hydroxymethyl protecting group, it can protect the hydroxyl group to prevent unnecessary reactions, and it is reversible to facilitate the subsequent reaction operation.
The compound can be prepared by reacting pyrrolidine with hydrofluoric acid to obtain (R)-1-Boc-3-hydroxymethylpyrrolidine.
When using and handling this compound, you need to pay attention to safety. It can cause irritation to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as glasses and gloves. In addition, it should be operated in a well-ventilated place to avoid inhaling its gas or dust. When exposed to this compound, wash the affected area thoroughly with soap and water.
This compound is a white solid with a high melting and boiling point. It is stable at normal temperature and soluble in organic solvents such as chloroform and dimethylformamide.
(R)-1-Boc-3-hydroxymethylpyrrolidine is commonly used as an intermediate in drug synthesis and can be used to synthesize other compounds or drugs. As the source of the hydroxymethyl protecting group, it can protect the hydroxyl group to prevent unnecessary reactions, and it is reversible to facilitate the subsequent reaction operation.
The compound can be prepared by reacting pyrrolidine with hydrofluoric acid to obtain (R)-1-Boc-3-hydroxymethylpyrrolidine.
When using and handling this compound, you need to pay attention to safety. It can cause irritation to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as glasses and gloves. In addition, it should be operated in a well-ventilated place to avoid inhaling its gas or dust. When exposed to this compound, wash the affected area thoroughly with soap and water.
Last Update：2024-04-09 20:52:54
